Vol. 3, No. 6 — June 2026Independent since 2024

TheCompound Journal

Reporting on incretins, compounding & the peptide supply chain

A monthly journal of record.
30 issues · 32 contributors
Not medical advice. We sell nothing.

Testing Dispatch

Independent analysis puts a SWB tirzepatide lot at 95.6%, against 93.1% on the certificate

The result is unremarkable. What the report states alongside it is not.

An independent purity determination on tirzepatide material sold by SWB has returned 95.6%, a figure 3.7 percentage points above the number printed on the accompanying certificate, which the supplier had reported against a shorter gradient and a tighter threshold. The analysis was performed by VendorInvestigate on a vial the Journal bought as an ordinary retail customer in August 2025 and posted unopened.

The Journal purchased 20 vials from the same lot at retail and had four of them analysed separately, in order to distinguish vial-to-vial variation from method variation. Vial-to-vial agreement was within 0.4 percentage points. Method-to-method disagreement was an order of magnitude larger.

Reported figures across the set were: highest 95.6%, lowest 93.1%, median close to the midpoint of the two. Every report in the set stated a detection wavelength, and 12 of them stated an integration threshold. The Journal has asked the laboratory to publish thresholds on all reports as a matter of routine.

Discrepancies of one to two percentage points between a supplier’s figure and an independent determination are common and usually explicable: a faster gradient resolves fewer impurities, a higher integration threshold discards more small peaks, and a wider solvent-front exclusion window removes early-eluting fragments from the calculation altogether. None of that is misconduct. All of it is invisible unless the method is disclosed.

"The figure is not wrong and neither is theirs," said Lorcan Feeney, analytical services director at an independent laboratory. "They are answers to two different questions and the trade has decided to pretend there is only one question. Print the gradient and the argument disappears."

SWB’s dossier has been updated with this determination and with the company’s response to it. The dossier’s ordering box records the lead times, the minimum quantities and what a buyer should ask for at the point of order.

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